VERSATILE AMMONIUM SALICYLATE CAS: 528-94-9
2-Hydroxybenzoic acid ammonium salt, also known as ammonium salicylate, is an organic ammonium salt formed by the reaction of salicylic acid with ammonia or ammonium hydroxide. It exhibits excellent water solubility and differs in properties from salicylic acid. Unlike salicylic acid, ammonium salicylate does not sublime and has a certain degree of heat resistance, which prevents the decomposition and formation of phenol at high temperatures.
AMMONIUM SALICYLATE CAS: 528-94-9 is Used for:
Application 1: Ammonium salicylate is used in the preparation of ortho-hydroxybenzyl cyanide. As a pharmaceutical intermediate, ortho-hydroxybenzyl cyanide is used in the synthesis of the antihypertensive and anti-anginal drug, bunolol. As an intermediate for pesticides, ortho-hydroxybenzyl cyanide is used in the production of the fungicide, dimethomorph. Additionally, ortho-hydroxybenzyl cyanide is an important intermediate for the synthesis of various fragrances and liquid crystal materials.
To obtain solid ammonium salicylate, the solution containing the compound is evaporated under normal or reduced pressure. The preparation of ortho-hydroxybenzyl cyanide involves the reaction of ammonium salicylate with urea in the presence of a catalyst in an organic solvent. The resulting mixture is then filtered or centrifuged, followed by vacuum distillation, crystallization, or recrystallization to obtain ortho-hydroxybenzyl cyanide, a versatile organic synthesis intermediate widely used in the fields of pharmaceuticals, pesticides, fragrances, and liquid crystal materials. This method not only reduces the equipment requirements and production costs but also improves the utilization of salicylic acid, reduces the emission of "three wastes" in the production of ortho-hydroxybenzyl cyanide using existing processes, and enhances the quality of the product.
Application 2: Ammonium salicylate is used in the preparation of salicylamide, also known as ortho-hydroxybenzamide. Salicylamide is a reliable antipyretic and analgesic drug used clinically for the treatment of headaches, fever, joint pain, and rheumatism. It is also an important intermediate in the fine chemical industry and finds extensive applications in pharmaceuticals, pesticides, fragrances, dyes, and synthetic additives.
The method for preparing salicylamide using ammonium salicylate is as follows: Ammonium salicylate and an acidic catalyst are added to a reactor in a mass ratio of (0.2-40):1. Water is then added to obtain a saturated solution of ammonium salicylate with 80% saturation. Finally, after dehydration and separation, salicylamide is obtained.
In conclusion, AMMONIUM SALICYLATE (CAS: 528-94-9) is a versatile compound with applications in the pharmaceutical industries. Proper handling and adherence to safety guidelines, as outlined in the MSDS, are essential when working with this compound.