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Idarubicin: Mechanism of Action, Side Effects, and Clinical Applications in Cancer Treatment

Idarubicin 57852-57-0is a potent chemotherapy drug belonging to the anthracycline class, primarily used in the treatment of various types of cancer, including acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL). Its mechanism of action, side effects, and clinical applications make it a crucial component of cancer treatment regimens.Mechanism of Action:Idarubicin exerts its anticancer effects by interfering with the DNA and RNA synthesis of cancer cells. It does so by intercalating between DNA base pairs, inhibiting the activity of topoisomerase II enzyme, and generating free radi [...]

Jan 23, 2026 Product News 1147 Views Read More

Exploring the Diverse Uses of Aminopterin: From Leukemia Treatment to Cell Culture

Aminopterin,cas: 54-62-6 also known as 4-aminopteroic acid, is a synthetic derivative of pterin and a 4-amino derivative of folic acid. It is an antineoplastic drug with immunosuppressive properties, often used in chemotherapy. Aminopterin functions as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase, effectively blocking tetrahydrofolate synthesis. This leads to the depletion of nucleotide precursors and the inhibition of DNA, RNA, and protein synthesis.Discovered by Yellapragada Subbarow, Aminopterin was first used by Sidney Farber in [...]

Jan 23, 2026 Product News 1357 Views Read More

Introduction to (-)-Methyl (R)-3-Hydroxypentanoate (CAS: 60793-22-8)

(-)-Methyl (R)-3-Hydroxypentanoate, also known as (R)-3-Hydroxypentanoic acid methyl ester, is an organic compound with a specific stereochemical configuration. It is commonly referred to as (-)-Methyl (R)-3-Hydroxypentanoate and is identified by its CAS number: 60793-22-8. This compound has attracted attention in various fields due to its potential applications and unique properties.Chemical Properties:(-)-Methyl (R)-3-Hydroxypentanoate is an ester derivative of (R)-3-Hydroxypentanoic acid. It possesses a chiral center with a specific (R)-configuration, indicating its stereochemistry. The com [...]

Jan 23, 2026 Product News 5987 Views Read More