2,5-Dichloropyrazine,CAS No :19745-07-4: Synthesis and Diverse Applications

2,5-Dichloropyrazine, CAS:19745-07-4 also known as 2,5-Dichloro-1,4-diazine, is a pharmaceutical intermediate with a molecular formula of C4H2Cl2N2 and a molecular weight of 148.98. This compound holds significant importance in various applications, and its synthesis process involves the chlorination of pyrazine-2-amine to obtain 5-chloropyrazine-2-amine, followed by diazotization to yield 2,5-Dichloropyrazine.Synthesis Process: The synthesis of 5-chloropyrazine-2-amine involves the addition of N-chlorosuccinimide (NCS) to a stirred solution of pyrazine-2-amine in anhydrous dichloromethane un [...]

Exploring the Diverse Uses of Aminopterin: From Leukemia Treatment to Cell Culture

Aminopterin,cas: 54-62-6 also known as 4-aminopteroic acid, is a synthetic derivative of pterin and a 4-amino derivative of folic acid. It is an antineoplastic drug with immunosuppressive properties, often used in chemotherapy. Aminopterin functions as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase, effectively blocking tetrahydrofolate synthesis. This leads to the depletion of nucleotide precursors and the inhibition of DNA, RNA, and protein synthesis.Discovered by Yellapragada Subbarow, Aminopterin was first used by Sidney Farber in [...]

Exploring the Significance of Allantoic Acid and Its Role in Biological Metabolic Pathway

Exploring the Significance of Allantoic Acid and Its Role in Biological Metabolic Pathway Allantoic acid, 99-16-1 also known as 2,2-bis(aminocarbonylamino)ethanoic acid, is a crystalline acid with the chemical formula C4H8N4O4. It is a significant organic compound found in nature and has various applications and properties.In nature, allantoic acid is produced from allantoin by the process of hydrolysis. It is a key intermediate in the metabolic pathway of purine degradation in organisms. Allantoate, an intermediate in the allantoin degradation to glyoxylate pathway, is the end [...]