Technical Analysis of 5-(Beta-Hydroxyethyl)-4-Methylthiazole-2-Carboxylic Acid (CAS 75113-60-9 )
5-(Beta-hydroxyethyl)-4-methylthiazole-2-carboxylic acid, also identified by CAS75113-60-9, is a high-value thiazole-based heterocyclic compound. With a
molecular formula of C7H9NO3S and a molecular weight of 187.22,
this molecule serves as a pivotal intermediate in the biosynthesis of thiamine (Vitamin B1).
Finetech Industry Limited provides
high-purity 5-(beta-hydroxyethyl)-4-methylthiazole-2-carboxylic acid to support
advanced research in microbial metabolic pathways, enzymology, and
pharmaceutical synthesis.
Role in Thiamine (Vitamin B1)
Biosynthesis
The biological significance of this
compound centers on its role in the thiazole moiety formation during thiamine
biosynthesis. In microbial and plant systems, the enzyme-mediated synthesis of
thiamine requires specific thiazole precursors.
1.
Pathway Integration: This compound is a key structural analogue in the enzymatic
reactions involving THI4
(yeast) or THI1
(plants).
2.
Cofactor Production: It facilitates the condensation with
4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate (HMP-PP) to form
thiamine monophosphate (TMP), the precursor to the active cofactor thiamine pyrophosphate (TPP).
3.
Metabolic Engineering: Researchers utilize this intermediate to study sulfur transfer
mechanisms and metabolic flux in vitamin biosynthesis.
Key Applications in Research and
Industry
1. Enzymology and Mechanism Studies
Due to its hydroxyl and carboxyl
functional groups, this molecule is an ideal substrate for examining enzyme
active-site interactions. It is widely used to probe the catalytic pathways of
thiazole-forming enzymes and sulfur-carrier proteins.
2. Medicinal Chemistry and Drug
Discovery
The thiazole scaffold is a
"privileged structure" in pharmacology.
5-(Beta-hydroxyethyl)-4-methylthiazole-2-carboxylic acid acts as a versatile building block for:
·
Antimicrobial Agents: Developing novel heterocycles targeting bacterial metabolism.
·
Anti-inflammatory Research: Synthesis of thiazole-based enzyme inhibitors.
·
Ligand Development: Construction of complex heterocyclic ligands for organic catalysis.
3. Microbial Biotechnology
In fermentation optimization and
microbial strain engineering, understanding the concentration and regulation of
this thiazole intermediate is crucial for maximizing vitamin production yields.
Technical Specifications (Finetech
Standard)
|
Property |
Specification |
|
CAS Number |
75113-60-9 |
|
Molecular
Formula |
C7H9NO3S |
|
Molecular
Weight |
187.22 |
|
Purity
(HPLC) |
95.0% |
|
Appearance |
Solid |
|
MDL Number |
MFCD01311030 |
|
Functional
Groups |
Thiazole
ring, Hydroxyl (-OH), Carboxylic acid (-COOH) |
Why Choose Finetech Industry Limited?
Finetech Industry Limited is a leading
global supplier of specialized research chemicals. We ensure that our CAS 75113-60-9 products meet
the most stringent laboratory requirements:
·
High Purity:
Guaranteed 95% purity via HPLC for consistent
experimental results.
·
Full Documentation: Every batch is provided with a Certificate of Analysis (COA), H-NMR, and SDS.
·
Global Supply Chain: Reliable logistics and flexible packaging options for academic and
industrial R&D.
References & Citations
1.
Chatterjee, A., et al. (2011). "The
Biosynthesis of Thiamine (Vitamin B1)." Chemical Society Reviews.
2.
Jurgenson, C. T., et al. (2009).
"The Structural Biology of Vitamin B1 Biosynthesis." Annual Review of
Biochemistry.
3.
Begley, T. P., et al. (1999).
"Thiamin Biosynthesis in Prokaryotes." Archives of Microbiology