A High-Purity Thiazole Intermediate for Innovation: CAS 75113-60-9
5-(2-Hydroxyethyl)-4-methyl-1,3-thiazole-2-carboxylic acid (CAS 75113-60-9): A High-Purity Thiazole Intermediate for Innovation
Overview of CAS 75113-60-9
In the competitive landscape of pharmaceutical and agrochemical synthesis, the choice of heterocyclic building blocks is paramount. Finetech Industry Limited offers high-quality 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole-2-carboxylic acid (CAS No. 75113-60-9). This versatile reagent is engineered for precision in medicinal chemistry, crop protection research, and advanced materials science.
Technical Specifications & Chemical Properties
Understanding the structural advantages of CAS 75113-60-9 is essential for synthetic route planning. This 1,3-thiazole derivative features three strategic functional handles:
C2-Carboxylic Acid Group: Facilitates rapid amidation and esterification, perfect for fragment-based drug discovery (FBDD).
C5-Hydroxyethyl Side Chain: A primary alcohol site that allows for etherification, oxidation, or the introduction of solubilizing groups to improve bioavailability.
C4-Methyl Substitution: Provides critical steric bulk to modulate the electronic environment of the thiazole ring, essential for Structure-Activity Relationship (SAR) optimization.
Primary Research Applications
1. Medicinal Chemistry & Drug Discovery
The thiazole scaffold is a "privileged structure" in pharmacology. Researchers utilize this intermediate to synthesize:
Anti-inflammatory and Antimicrobial Agents: Leveraging the thiazole ring's bioisosteric potential.
Enzyme Inhibitors: Acting as a core scaffold for kinase-modulating small molecules.
Metabolic Regulators: Enhancing the molecular diversity of lead compounds.
2. Agrochemical Development
As a heterocyclic carboxylic acid, this compound is a vital precursor in the development of:
Next-generation Fungicides: Building stable, bio-active heterocyclic frameworks.
Plant Growth Regulators: Utilizing the hydroxyethyl group for targeted functionalization.
3. Materials Science & Coordination Chemistry
Beyond biology, the N, S, and O heteroatoms make this compound an excellent candidate for:
Metal Coordination Complexes: Studying ligand-metal interactions.
Functional Polymers: Serving as a monomer or modifier to introduce heterocyclic properties into materials.
Why Choose Finetech Industry Limited?
Finetech Industry Limited is a leading supplier of research-grade chemicals. Our commitment to quality ensures that every batch of CAS 75113-60-9 meets rigorous standards:
Certified Purity: Validated via HPLC, NMR, and Mass Spectrometry (MS).
Batch Consistency: Ensuring reproducible results
Global Distribution: Secure, compliant packaging with worldwide shipping capabilities.
Conclusion
For laboratories focused on high-impact synthesis, 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole-2-carboxylic acid is more than just a reagent—it is a foundation for discovery. Contact Finetech Industry Limited today for technical data sheets (TDS) and pricing.
Keywords:
5-(2-hydroxyethyl)-4-methyl-1,3-thiazole-2-carboxylic acid
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CAS 75113-60-9
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thiazole building block
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heterocyclic intermediate
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medicinal chemistry thiazole
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agrochemical intermediate
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research chemical supplier
Technical Note:
Joule, J. A.; Mills, K.
Heterocyclic Chemistry, 5th Edition, Wiley, 2010.
Keri, R. S. et al.
Thiazole and its derivatives: A review on recent progress in biological activities.
European Journal of Medicinal Chemistry, 2015, 89, 207–251.
DOI: 10.1016/j.ejmech.2014.10.054
Sharma, P. C. et al.
Thiazole-containing compounds as potential therapeutic agents.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, 24(4), 890–897.
Zhang, L. et al.
Heterocyclic carboxylic acids in agrochemical discovery.
Pest Management Science, 2018.